Development and Evaluation of a New Triplex Immunoassay That Detects Group A Streptococcus Antibodies for the Diagnosis of Rheumatic Fever

AL Whitcombe, P Hanson-Manful, S Jack… - Journal of clinical …, 2020 - Am Soc Microbiol
Streptococcal serology is a cornerstone in the diagnosis of acute rheumatic fever (ARF), a
postinfectious sequela associated with group A Streptococcus infection. Current tests that …

The novel group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute …

P Hanson-Manful, AL Whitcombe, PG Young… - Journal of Infection, 2018 - Elsevier
Objectives Streptococcal serology provides evidence of prior Group A Streptococcus (GAS)
exposure, crucial to the diagnosis of acute rheumatic fever (ARF) and post-streptococcal …

Comprehensive analysis of antibody responses to streptococcal and tissue antigens in patients with acute rheumatic fever

TB Martins, JL Hoffman, NH Augustine… - International …, 2008 - academic.oup.com
Acute rheumatic fever (ARF) is an autoimmune disease occurring in individuals following
untreated group A streptococcal infection believed to be triggered by antibodies to bacterial …

Increased Breadth of Group A Streptococcus Antibody Responses in Children With Acute Rheumatic Fever Compared to Precursor Pharyngitis and Skin Infections

AL Whitcombe, R McGregor, J Bennett… - The Journal of …, 2022 - academic.oup.com
Abstract Background Group A Streptococcus (GAS) causes superficial pharyngitis and skin
infections as well as serious autoimmune sequelae such as acute rheumatic fever (ARF) …

An eight-plex immunoassay for Group A streptococcus serology and vaccine development

AL Whitcombe, F Han, SM McAlister… - Journal of …, 2022 - Elsevier
Abstract Group A Streptococcus (GAS) is a major human pathogen responsible for
superficial infections through to life-threatening invasive disease and the autoimmune …

Development of a multiplexed fluorescent immunoassay for the quantitation of antibody responses to group A streptococci

TB Martins, NH Augustine, HR Hill - Journal of immunological methods, 2006 - Elsevier
The host immunologic response to group A streptococcal infections gives rise to numerous
antibodies directed against cellular and extracellular bacterial antigens. For determining …

Streptococcal serology in acute rheumatic fever patients: findings from 2 high-income, high-burden settings

S Jack, NJ Moreland, J Meagher, M Fittock… - The Pediatric …, 2019 - journals.lww.com
Background: Globally, there is wide variation in streptococcal titer upper limits of normal
(ULN) for antistreptolysin O (ASO) and anti-deoxyribonuclease B (ADB) used as an …

Streptococcal antibody tests in rheumatic fever

NM Burdash, G Teti, P Hund - Annals of Clinical & Laboratory …, 1986 - Assoc Clin Scientists
Although the incidence of rheumatic fever has declined significantly over the last decade,
testing for antibodies to streptococcal extracellular enzymes maintains an important role in …

Serological evidence of immune priming by group A streptococci in patients with acute rheumatic fever

JM Raynes, HRC Frost, DA Williamson… - Frontiers in …, 2016 - frontiersin.org
Acute rheumatic fever (ARF) is an autoimmune response to Group A Streptococcus (GAS)
infection. Repeated GAS exposures are proposed to 'prime'the immune system for …

Group A streptococcal antibodies in subjects with or without rheumatic fever in areas with high or low incidences of rheumatic fever

EM Ayoub, B Nelson, ST Shulman… - Clinical and Vaccine …, 2003 - Am Soc Microbiol
The levels of streptococcal antibody titers in populations with or without rheumatic fever from
an area with a relatively high incidence of rheumatic fever and an area with a low incidence …