Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries

S Bonassi, H Norppa, M Ceppi, U Strömberg… - …, 2008 - academic.oup.com
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has
been recently supported by the results of epidemiological studies that associated CA …

Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study

S Bonassi, A Abbondandolo, L Camurri… - Cancer genetics and …, 1995 - Elsevier
To investigate the existence of an association between the frequency of chromosome
aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried …

Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH)

L Hagmar, S Bonassi, U Strömberg, A Brøgger… - Cancer research, 1998 - AACR
Chromosomal aberrations (CAs), sister chromatid exchanges (SCEs), and micronuclei (MN)
in peripheral blood lymphocytes have for decades been used as cytogenetic biomarkers to …

Chromosomal aberrations and cancer risk: results of a cohort study from Central Europe

P Boffetta, O van der Hel, H Norppa… - American journal of …, 2007 - academic.oup.com
A high level of chromosomal aberrations in peripheral blood lymphocytes may be an early
marker of cancer risk, but data on risk of specific cancers and types of chromosomal …

Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer

P Rossner, P Boffetta, M Ceppi, S Bonassi… - Environmental …, 2005 - ehp.niehs.nih.gov
There is evidence that increased frequency of chromosomal aberration (CA) in peripheral
blood lymphocytes is a predictor of cancer, but further data are needed to better characterize …

Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts

L Hagmar, U Strömberg, S Bonassi, IL Hansteen… - Cancer research, 2004 - AACR
The frequency of cells with structural chromosomal aberrations (CAs) in peripheral blood
lymphocytes is the first genotoxicity biomarker that has shown an association with cancer …

Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective

S Bonassi, A Znaor, H Norppa, L Hagmar - Cytogenetic and genome …, 2004 - karger.com
The pioneering papers published more than one century ago by Theodor Boveri opened the
way to extensive research on the mechanism linking chromosomal abnormalities to the …

Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens

S Bonassi, L Hagmar, U Strömberg, AH Montagud… - Cancer Research, 2000 - AACR
An increased risk of cancer in healthy individuals with high levels of chromosomal
aberrations (CAs) in peripheral blood lymphocytes has been described in recent …

Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes.

C Bolognesi, A Abbondandolo, R Barale… - … , biomarkers & prevention …, 1997 - AACR
Intra-and interindividual variations of baseline frequencies of cytogenetic end points in
lymphocytes of human populations have been reported by various authors. Personal …

Chromosomal aberrations and SCEs as biomarkers of cancer risk

H Norppa, S Bonassi, IL Hansteen, L Hagmar… - Mutation Research …, 2006 - Elsevier
Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but
not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined …