… therapy remain the leading cancer treatment options for patients around the globe. However,
these “traditional” therapies target … Recently, the development of emerging targeted therapy …

… important therapeutic target in many types of cancer 5 . Although memory T-cells and cytotoxic
T-cells were observed in high densities compared with other cell populations, various cell …

… –B7-H4 antibody treatment can stimulate IFNy secretion … therapeutic target because it was
highly expressed in ACC-I, had a strong association with poor prognosis, and is a drug target …

… However, scoring was similar among different blocks from each tumor, indicating that the
spatial distribution of heterogeneity of expression of PD-L1 is within the area represented in a …

… We envision that a similar approach combining spatial immunoprofiles with genomic alteration
data and immunotherapy treatment response could deepen our understanding of tumor …

… development of personalized immunotherapy treatments have become a central goal in
immuno-oncology, our understanding of how such therapies act at the tumour site is still limited. …

… IO Drug Target module and Immune Cell Typing module (38 antibodies in total). The
quantification capability of the approach was assessed by measuring the readouts generated from …

… The extent of spatial and functional heterogeneity, however, is much less understood. In
the present study, digital spatial profiling identified the tumor periphery as a highly active …

… (IHC) and mRNA immunoprofiling, we found that they lack signs … potential therapeutic targets
for immunomodulation. … time detailed mRNA immunoprofiling including spatially resolved, …

… Proteomic immunoprofiling may help clinically distinguish between different histologic
subtypes of DM. Spatial expressions of checkpoints intratumorally and within LA demonstrate …