The effect of surface charge on oral absorption of polymeric nanoparticles

XJ Du, JL Wang, S Iqbal, HJ Li, ZT Cao, YC Wang… - Biomaterials …, 2018 - pubs.rsc.org
surface charge facilitated the cellular uptake and transport of nanoparticles through both
Caco-2 cells in vitro and small intestinal … the effect of surface charge on the intestinal cell uptake, …

Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration

C Schleh, M Semmler-Behnke, J Lipka, A Wenk… - …, 2012 - Taylor & Francis
… -charged particle could obtain a negative surface charge and vice versa. We hypothesize that
in our experiments the surface charge … -charged particles exhibit a higher absorption in the …

[HTML][HTML] … nanoparticles in the process of the intestinal absorption based on model nanoparticles with various characteristics: size, surface charge and pro-hydrophobics

S Guo, Y Liang, L Liu, M Yin, A Wang, K Sun… - Journal of …, 2021 - Springer
… of particle size, surface charge, and surface hydrophilicity/… to overcome the intestinal barrier
and achieve oral absorption, by … each stage of the intestinal absorption process is specifically …

Mechanisms of nanoparticle internalization and transport across an intestinal epithelial cell model: effect of size and surface charge

AM Bannunah, D Vllasaliu, J Lord… - Molecular …, 2014 - ACS Publications
… ) and surface charge on their interaction with Caco-2 monolayers as a model of the intestinal
… were dependent on the surface charge and applied mass, number, and total surface area of …

Proliposome powders for enhanced intestinal absorption and bioavailability of raloxifene hydrochloride: effect of surface charge

A Velpula, R Jukanti, KY Janga… - Drug development …, 2013 - Taylor & Francis
… -pass intestinal absorption study data in rats provide an insight on the potential of proliposomes
and cationic surface charge for augment in absorption across gastro intestinal barrier. To …

Mechanism of surface charge triggered intestinal epithelial tight junction opening upon chitosan nanoparticles for insulin oral delivery

J Wang, M Kong, Z Zhou, D Yan, X Yu, X Cheng… - Carbohydrate …, 2017 - Elsevier
… The above in vivo results confirmed that the enhanced insulin absorption could be determined
by the surface charge property of CMCS/CS-NPs, which were consistent with the results …

Use of surface charges from DFT calculations to predict intestinal absorption

R Jones, PC Connolly, A Klamt… - Journal of chemical …, 2005 - ACS Publications
… for which the surface polarization charges have been … intestinal absorption, where the
intestinal epithelium cannot be completely described, and to derive a general absorption

Effect of particle size and surface charge of nanoparticles in penetration through intestinal mucus barrier

SP Bandi, YS Kumbhar, VVK Venuganti - Journal of Nanoparticle …, 2020 - Springer
… of amino surface. In conclusion, the most desirable particle size and surface charge for …
The small intestine is an essential site for drug absorption within the gastrointestinal tract. …

Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin

DA Norris, PJ Sinko - Journal of applied polymer science, 1997 - Wiley Online Library
… Louis, MO) or Fisher Scientific (Springfield, nificant barrier to the intestinal absorption of
NJ) … the effects of surface charge in the current study. Glen Leesman (Ribi ImmunoChem …

Positive/negative surface charge of chitosan based nanogels and its potential influence on oral insulin delivery

J Wang, M Xu, X Cheng, M Kong, Y Liu, C Feng… - Carbohydrate …, 2016 - Elsevier
… exhibited different adhesion and permeation in specific intestinal segments. … the surface
charge property of nanogels determined the absorption sites of CMCS/CS-NGs in small intestine