Traumatic brain injury as a trigger of neurodegeneration

VE Johnson, W Stewart, JD Arena, DH Smith - Neurodegenerative …, 2017 - Springer
Although millions of individuals suffer a traumatic brain injury (TBI) worldwide each year, it
is only recently that TBI has been recognized as a major public health problem. Beyond the …

[HTML][HTML] Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans

S Bagnato, C Boccagni - Neural regeneration research, 2020 - journals.lww.com
… years after the acute injury, potentially leading to neuronal loss and brain atrophy. Very little
triggers various mechanisms capable of inducing prolonged neurodegeneration in humans. …

Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic …

PM Washington, S Villapol, MP Burns - Experimental neurology, 2016 - Elsevier
… a risk factor for multiple types of neurodegenerative disease. The question becomes whether
we should view TBI as a trigger for individual neurodegenerative diseases, or if we should …

Molecular mechanisms of acute brain injury and ensuing neurodegeneration

FJ Ortega, JM Vidal-Taboada, N Mahy… - Brain Damage …, 2012 - books.google.com
trigger calcium-mediated excitotoxicity in several rat brain areas and induce an ongoing
neurodegenerative … agonist in the rat medial septum triggers a persistent process that leads to a …

[HTML][HTML] Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration

F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
… microglia in neurodegeneration after injury, … neurodegeneration after injury. The work will
give us a comprehensive understanding of mechanisms driving TBI-related neurodegeneration

Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

NSN Graham, DJ Sharp - Journal of Neurology, Neurosurgery & …, 2019 - jnnp.bmj.com
… Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s …
can trigger neurodegeneration are increasingly understood. For example, diffuse axonal injury is …

[HTML][HTML] Traumatic brain injury: a risk factor for neurodegenerative diseases

R Gupta, N Sen - Reviews in the Neurosciences, 2016 - degruyter.com
brain injury (TBI) may be defined as ‘an alteration in brain function … Brain injuries can be
classified into mild, moderate, and … as possible triggers of the neurodegenerative sequel in ALS, …

[HTML][HTML] Persistent neurovascular unit dysfunction: pathophysiological substrate and trigger for late-onset neurodegeneration after traumatic brain injury

Y Zhou, Q Chen, Y Wang, H Wu, W Xu, Y Pan… - Frontiers in …, 2020 - frontiersin.org
… cause of functional impairment in brain injury or neurodegenerative diseases, and almost
all the therapeutic strategies were targeted at repairing neuronal injury and rescuing neurons (…

Injury cascades in TBI-related neurodegeneration

ST DeKosky, BM Asken - Brain injury, 2017 - Taylor & Francis
… Traumatic brain injury (TBI) and neurodegenerative disease are both international public …
TBI may elevate risk of developing neurodegenerative pathology by a variety of potential …

[HTML][HTML] Mild traumatic brain injury: a risk factor for neurodegeneration

BE Gavett, RA Stern, RC Cantu, CJ Nowinski… - Alzheimer's research & …, 2010 - Springer
trigger for the development of neurodegenerativebrain injury (TBI), including repetitive
concussive and subconcussive trauma, can provoke another distinctive neurodegeneration