Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

NSN Graham, DJ Sharp - Journal of Neurology, Neurosurgery & …, 2019 - jnnp.bmj.com
… Blood and CSF levels increase acutely after brain injury and relate to the severity of injury.
s65 53 Concentrations in blood and CSF rise briskly after even mild injuries, such as following …

Traumatic brain injury and risk of neurodegenerative disorder

BL Brett, RC Gardner, J Godbout, K Dams-O'Connor… - Biological …, 2022 - Elsevier
… It is important to consider the structural effects of TBI, acutely and over time, to understand
how neurodegenerative disease processes may unfold postinjury, as well as the way in which …

Traumatic brain injury, neuroimaging, and neurodegeneration

ED Bigler - Frontiers in human neuroscience, 2013 - frontiersin.org
understand (1) the dynamic changes that occur in brain development relevant to understanding
… in this review which examines volume loss from brain injury, its role in the aging process, …

Recent advances in our understanding of neurodegeneration

KA Jellinger - Journal of neural transmission, 2009 - Springer
Neurodegenerative diseases are featured by progressive … the hallmarks of many
neurodegenerative disorders, summarized as … Neurodegenerative disorders are classified …

Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

M Cruz-Haces, J Tang, G Acosta, J Fernandez… - … neurodegeneration, 2017 - Springer
… to understand the pathophysiological mechanisms of traumatic brain injury and
neurodegeneration in order to identify potential factors that initiate neurodegenerative processes. …

Traumatic brain injury: a risk factor for neurodegenerative diseases

R Gupta, N Sen - Reviews in the Neurosciences, 2016 - degruyter.com
… reports suggest the link between the dysregulation of the ubiquitin-protease system and
an accumulation of Aβ levels in TBI (Magnoni and Brody, 2010); however, our understanding

Injury cascades in TBI-related neurodegeneration

ST DeKosky, BM Asken - Brain injury, 2017 - Taylor & Francis
… with heightened risk of neurodegenerative outcomes, but specific … Our understanding of a
pathological signature associated … Traumatic brain injury (TBI) and neurodegenerative disease …

Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration

F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
injuries, traumatic brain injury is associated with a number of chronic neurological and
neuropsychiatric sequelae including neurodegenerative … TBI will facilitate our understanding of …

Molecular mechanisms of acute brain injury and ensuing neurodegeneration

FJ Ortega, JM Vidal-Taboada, N Mahy… - Brain Damage …, 2012 - books.google.com
… including stroke, traumatic brain injury and spinal cord injury, cause … will emerge from an
understanding of the interdependence … Acute brain injury can also activate a neurodegenerative

Cellular players that shape evolving pathology and neurodegeneration following traumatic brain injury

SS Puntambekar, M Saber, BT Lamb… - Brain, behavior, and …, 2018 - Elsevier
… implicate chronic post-injury neuroinflammation as a potential catalyst for TBI-related
neurodegeneration and cognitive decline. The lack of a clear understanding of the complexity of …