… gene delivery to vestibular supporting cells. To further provide cell type selectivity of gene
delivery, we … Delivery of this vector to IDPN-damaged vestibular organs resulted in a significant …

… will want to optimize the gene delivery methodology, dosing and … The use of these gene
delivery approaches are attractive for … The incidence of peripheral vestibular disease is largely …

… invasive injections, direct delivery to the ear may be a more practical route for tissue-limited
diseases such as hearing and vestibular disorders. Local delivery has the accessory …

… insertional mutagenesis, and viral vector-related disease or toxicity, vesicles composed of a
… DNA to produce cationic liposomes as drug or gene delivery vectors. Liposomes bind to the …

… Currently vestibular diseases have few treatment options … in the vestibular system. Development
of atoh1-based … -mediated gene delivery to damaged vestibular neuroepithelium, we …

… , prevention of oxidative stress, and regeneration of both auditory and vestibular hair cells. …
gene and are particularly suited for targeting neurons. Liposomal or nonviral gene delivery …

… genetic knowledge base for vestibular disorders is still in its infancy. Identifying the genetic
… and the disease etiology and process. There is an increasing effort to use new and efficient …

… of effects caused by any particular pharmacologic agent or gene delivery vector. We
accomplished this by assaying hearing and vestibular function before and after inner ear injection of …

… Our results open up new perspectives for efficient gene therapy of cochlear and vestibular
disorders by showing that even severe dysmorphogenesis of stereociliary bundles can be …

… and vestibular function in a mouse model of Usher syndrome [38] These studies demonstrate
the potential of transgene therapy for restoring hearing in cases of genetic hearing loss. …