… The affinity of prazosin for [1251]-Heat binding sites was … adrenergic receptor subtypes
in smooth muscle of human … Binding properties of alpha-1 adrenergic receptors in rat …

… heart failure, and benign prostatic hyperplasia (BPH). In particular, the role of α1 AR … The
percentage of high affinity sites was calculated by … Alpha-1 adrenoceptor subtypes in the human …

… Alpha 1 -receptors can either be native (denoted by upper-… subtype (α 1L ) was identified
that has affinity for prazosin and … in vascular and extraprostatic tissues. Tamsulosin binding is …

… of benign prostatic hyperplasia (BPH) and lower urinary tract … non subtype selective alpha1-AR
blockers, such as prazosin, … -AR selective antagonists with low alpha1B-AR affinity. Since …

… 1 antagonist therapy for benign prostatic hyperplasia, the most … -AR subtype could be detected
in human prostate in a tissue … in mammalian tissues with even lower affinity for prazosin. …

… binding studies using [ 3 H]prazosin/[ 125 I]HEAT and [ 3 H]L-771.688 in human and animal
… the tissue to NE. The estimation of affinity (p A2 -value) at alpha 1 -adrenoceptors mediating …

… as myocardial hypertrophy and benign prostatic hyperplasia, the … affinity for the α 1 AR
antagonist prazosin) has been … α 1 AR subtype expression and functionality in a given tissue. At …

… and in the treatment of benign prostatic hyperplasia. … in comparison to prazosin for the
lower urinary tract tissues vs. the car… rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype. …

… effects of naftopidil and prazosin on the development of … for the treatment of benign prostatic
hypertrophy, is shown to … of alpha 1—adrenergic receptor subtype mRNA in rat tissues …

… This drug can be used for the treatment of benign prostatic hypertrophy … affinity of tamsulosin
(pKi 7.87) to ·1L-AR subtype in the canine aorta was shown to be lower than that of prazosin …