[HTML][HTML] A predictive pharmacokinetic/pharmacodynamic model of fentanyl for analgesia/sedation in neonates based on a semi-physiologic approach

E Encinas, R Calvo, JC Lukas, V Vozmediano… - Pediatric drugs, 2013 - Springer
… Despite the existing controversy regarding selection of either morphine or fentanyl within … )
and receptor binding of fentanyl, compared with morphine, enable easier access to the central …

[HTML][HTML] Translational pain research: Evaluating analgesic effect in experimental visceral pain models

AE Olesen, T Andresen, LL Christrup… - World journal of …, 2009 - ncbi.nlm.nih.gov
… used a sheep preparation to examine the cerebral kinetics … Morphine: Morphine is a highly
potent opiate analgesic drug … : to what extent do the cerebral pharmacokinetics of a drug …

The history and development of the fentanyl series

TH Stanley - Journal of pain and symptom management, 1992 - Elsevier
… that meperidine was not a suitable alternative to morphine as … and other desirable
pharmacokinetic characteristics. Sufentanil is … 5 mg/kg of alfentanil. Transient increases in …

Theoretical aspects of P-glycoprotein mediated drug efflux on the distribution volume of anaesthetic-related drugs in the brain

RN Upton - Anaesthesia and intensive care, 2002 - journals.sagepub.com
… The brain concentrations of morphine have been shown to be two- to five-fold higher
when P-… The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep. …

Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug …

JP van den Berg, HEM Vereecke… - BJA: British Journal …, 2017 - academic.oup.com
… Generally, in a sheep model, cardiac output is found to be inversely related to arterial and
… of 50% probability for return of consciousness. Midazolam and alfentanil tend to act supra-…

American College of Chest Physicians consensus statement on the use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy in adult patients

…, M Jantz, P Lee, GB Mackensen, SY Barbour, C Lamb… - Chest, 2011 - Elsevier
… ) and midazolam was compared with midazolam alone. … and ketamine or propofol and
alfentanil using a patient-controlled … of propofol with a pharmacokinetic and pharmacodynamic …

Reduction and lumping of physiologically based pharmacokinetic models: prediction of the disposition of fentanyl and pethidine in humans by successively simplified …

S Björkman - Journal of pharmacokinetics and pharmacodynamics, 2003 - Springer
… flows on the pharmacokinetics of fentanyl and alfentanil in patients. Anesthesiology 88:657–667
(1998). … The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep. …

Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat.

H Buerkle, TL Yaksh - British Journal of Anaesthesia, 1998 - academic.oup.com
… Comparison of the spinal actions of the mu-opioid remifentanil with alfentanil and morphine
in the … Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep. …

Opioids

B KuKanich, AJ Wiese - … and analgesia: The fifth edition of …, 2015 - Wiley Online Library
… with microinjection of morphine into various brain sites [33]. … Goats, pigs, sheep, and cattle
exhibit more MAC‐sparing … The pharmacokinetics and locomotor activity of alfentanil in …

Trends in the pharmacology of opioids: implications for the pharmacotherapy of pain

LE Mather - European Journal of Pain, 2001 - Elsevier
… The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep.
Anesthesiology 1997; 86: 1317±1325. Wang JB, Johnson PS, Imai Y, Persico AM, Ozenberger BA, …