… coagulation and fibrinolysis in ALI/ARDS and emphasize gaps … has been shown to inhibit
surfactant function which could … Future studies of ART-123 in both experimental models of …

… models of ALI/ARDS in which exogenous surfactant therapy has … [180] in 42 children at eight
centers with ALI/ARDS showed that … Future work perfecting more efficient aerosol delivery …

… surfactant administration to assess whether this therapy may … administration may be a
potential promising path of future … approach [19, 20] while one trial used traditional tidal volumes […

… the alveolus has led to the inactivation of surfactant. (From Ware LB, … of ALI/ARDS primarily
through release of systemic cytokines. Following both direct and indirect initiators of ALI/ARDS…

… Additionally, AT II cells secrete pulmonary surfactants … During ALI/ARDS pathology,
overexpression of chemokine … To facilitate future research on applications of nanomedicines …

… for the loss of alveolar surfactant during ARDS. … surfactant therapy has improved oxygenation
and reduced mortality in children with ARDS ( 84 , 85 ). Although exogenous surfactant …

… approaches to the treatment of ARDS are reviewed. Future treatments should be targeted at
elements of … The optimum timing and duration of surfactant therapy is still to be determined. …

… Coagulation cascade abnormalities are characteristic in ALI/ARDS … therapeutic targets for
patients with ALI/ARDS in the future. … However, at present exogenous surfactant has no added …

… a description of completed and future clinical trials in humans with … a major pathogenic
role in ALI/ARDS. Despite promising … of aspirin administration on ARDS development in at-risk …