levo-α-Acetylmethadol (LAAM) is a long-acting opioid agonist prodrug used for preventing
opiate withdrawal. LAAM undergoes bioactivation via sequential N-demethylation to nor-…

… This review will highlight some specific examples of atypical kinetics, as well … atypical kinetics
with respect to in vitro-in vivo correlations. In addition, artifactual sources of atypical kinetic …

… Levo-α-acetylmethadol (LAAM) is a methadone derivative used to treat the opiate addict. We
previously reported on the kinetics … norLAAM exhibited monophasic kinetics with apparent K …

… Methadone and levo-α-acetylmethadol (LAAM) are opioid … tolevo-α-acetyl-N-normethadol
(nor-LAAM) andlevo-α-acetyl-N,N… multienzyme kinetics that were similar to the multisite kinetics …

… and KHARASCH, ED, 2001, Metabolism of levo-alpha-Acetylmethadol (LAAM) by human
liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two …

… interestingly showed a biphasic kinetic profile with apparent … also revealed biphasic
nonsaturable kinetics with apparent K … Based on kinetic data corrected for the relative activity …

… , kinetic studies of these P450s showed a sigmoidal behaviour. Atypical kinetics was …
of two molecules of flavone in the active site of PcCYP50c that supports the atypical kinetics. …

… levo-α-acetylmethadol, naphthalene, and nor-levo-α-… kinetics are the most common atypical
kinetic profiles observed, a few cases of heteroactivation have been reported. Atypical kinetic …

Objective: Levo-α-acetylmethadol (LAAM, levacetylmethadol) is a long-acting opioid agonist
used for the prevention of opioid withdrawal. LAAM undergoes sequential N-demethylation …

… , and thus are becoming more cognizant of these atypical kinetic events. This is reflected
by the increase in atypical kinetic profiles reported in the literature over the past few years. …