… dose. We conclude that nonlinearity of morphine BBB transport affects the relative brain
ECF exposure and the fluctuation of morphine and its metabolites mainly at lower dosing …

… the dose-effect relationships of morphine, we investigated the effects of its non-linear blood–brain
… profiles for morphine, M3G and M6G for clinically relevant dosing regimens based on …

… From a clinical point of view, a T max in the order of 30 min is in the same range as the
time to maximum analgesia after an intravenous bolus dose of morphine [23]. The tendency …

… changed with increasing dose. We conclude that nonlinearity of morphine BBB transport
affect the relative brain ECF exposure and the fluctuation of morphine and its metabolites. …

… of the blood-brain barrier (BBB) transport to the delay in antinociceptive effect of morphine-6-…
and therefore a higher analgesic activity can be expected for M6G than morphine on a dose …

… Probenecid was administered as a bolus dose of 20 mg/kg followed by a constant infusion
of 20 … This work was supported by the Swedish foundation for strategic research, Stockholm, …

… (CNS) in order to develop suitable therapeutic strategies to treat this menace of the society.
… GFAP immunostaining during morphine dependence caused by single low dose of the …

… morphine and/or its withdrawal may cause severe stress that could affect the properties of the
blood–brain … chronically given morphine is altered from 1 day after the last morphine dose, …

… for morphine and its glucuronide metabolites revealed for the first time that both M6G and
M3G were present in abundance after chronic oral dosing with morphine.… -mediated strategy. J …

… ) strategy was first adopted for the … dose of morphine (1 mg/kg), Nal (0.5 mg/kg), and Nal-M
(0.5 mg/kg) was administered on the basis of literature data (40). A single intravenous dose of …