… to characterize the dose-dependent pharmacokinetics of buprenorphine (BN) and
norbuprenorphine (NBN), the primary metabolite, after intravenous administration of different doses …

… administration of buprenorphine or norbuprenorphine in rats, the analgesic effect of
norbuprenorphine … after an intravenous bolus administration of norbuprenorphine decreased in a …

The relationships between plasma or brain concentrations and analgesic effects of both
buprenorphine(BN) and an active metabolite, norbuprenorphine(NBN), were investigated in rats…

… Mice (n = 48) were given 2.4 mg/kg buprenorphine (HCl salt) by intravenous bolus injection,
… drug administration. Plasma concentrations of buprenorphine and norbuprenorphine were …

… boluses or the combinations of buprenorphine and morphine [43]. The overall daily intravenous
buprenorphine dose … levels of buprenorphine and its metabolite nor-buprenorphine, and …

… depression induced by buprenorphine and its active metabolite, norbuprenorphine (NBN),
was … After iv bolus administration of buprenorphine no effects were noted over the dose range …

… of norbuprenorphine, an N-dealkyl metabolite of buprenorphine… intravenous lethal dose
(LD 50 ) of norbuprenorphine in … intravenous dose of 3 or 9 mg/kg norbuprenorphine alone on …

… the plasma concentrations of buprenorphine and norbuprenorphine. Pain ratings taken …
morphine bolus, the dose being 1/5 of the morphine equivalent daily dose of buprenorphine. For …

… Injecting relatively large bolus … administration to rodents. Experiments conducted in the
author's laboratory 40 have shown that norbuprenorphine is equi-efficacious with buprenorphine: …

… An active metabolite of buprenorphine, norbuprenorphine, was alone … for buprenorphine
protecting against norbuprenorphine-… administration of buprenorphine and norbuprenorphine …