… Buprenorphine and its active metabolite norbuprenorphine have both agonist and … (PCA
settings should include boluses only, as the patient’s baseline buprenorphine should take the …

… boluses or the combinations of buprenorphine and morphine [43]. The overall daily intravenous
buprenorphine dose … levels of buprenorphine and its metabolite nor-buprenorphine, and …

… Our group previously reported that intravenous (IV) administration of buprenorphine (BUP)
reduces pain intensity ratings while also modulating activity in CNS circuitry that mediates …

… of buprenorphine and its active metabolite, norbuprenorphine, in dogs following a combined
bolus-CRI IV administration, … of buprenorphine administered postoperatively as an IV bolus …

… Bolus doses were delivered by intravenous patient-controlled anesthesia, with a bolus
lockout … Study end points included total opioid consumption (infusion + boluses), demand:delivery …

… In conclusion, our results suggest that one single subcutaneous injection of buprenorphine
followed by buprenorphine in drinking water may be a viable treatment option for the relief of …

… He received 3 boluses of … buprenorphine and norbuprenorphine are primarily excreted in
the feces. The elimination half-life of buprenorphine is 37 hours after sublingual administration; …

… Plasma concentrations of buprenorphine and its major metabolite norbuprenorphine were
… administration, with no evidence of an immediate bolus effect. The average buprenorphine …

… (120 μg kg –1 in Doodnaught et al., 20 μg kg –1 in Johnson et al., 40 μg kg –1 in the current
study); mode of administration (intravenous bolus in Doodnaught et al. and Johnson et al., …

… active metabolite norbuprenorphine in the … bolus dose9. The results of a study in healthy
volunteers showed that peak depression of ventilation after IV administration of buprenorphine …