… of buprenorphine (BUP) and norbuprenorphine (norBUP) in sheep were characterized. …
These data were fitted to physiologically based pharmacokinetic models. BUP cerebral …

… Sheep are used to model interventions targeting airway … methanol plus a buprenorphine-D4
and norbuprenorphine-D3 … for buprenorphine and 0.4 to 200 ng/mL for norbuprenorphine. …

… Buprenorphine and its metabolite, norbuprenorphine, were … µg/L for buprenorphine and
norbuprenorphine, respectively. … pregnant sheep and indicate the feasibility of our sheep model …

… buprenorphine and norbuprenorphine concentrations were determined. During the exposure
period the sheep … reasons, we utilized a pregnant sheep model. BUP was administered …

… technique, buprenorphine and norbuprenorphine were extracted from sheep plasma. A 200
mL … Sheep are widely used in experimental surgical models and very often require adequate …

… In this thesis, I have attempted to investigate this topic by using a pregnant sheep model
to evaluate BUP pharmacokinetics, fetal exposure, and CNS distribution, as this type of study …

… Norbuprenorphine was analyzed from all plasma, cerebrospinal … The current study
demonstrates that buprenorphine … executed the study in an animal model that correlates well with …

… The bioavailability of buprenorphine, HCl (BPP) in sheep after nasal administration of
two … A two-compartment model with initial and terminal serum half-lives of 10 and 23 min, …

… In sheep, norbuprenorphine also had respiratory depressant effects.24Unlike … -3-glucuronide
(C ), and norbuprenorphine-3-glucuronide (D ) in an acute pain model. Time to withdrawal …

… of buprenorphine and its metabolite norbuprenorphine in … (following a sigmoid I max
model) according to the following … in sheep (Nolan et al. 1987) and cats (Steagall et al. 2007). …