Overview of brain microdialysis

VI Chefer, AC Thompson, A Zapata… - Current protocols in …, 2009 - Wiley Online Library
… of tissue trauma on the interpretation of microdialysis results, … rate of DA uptake in the vicinity
of the microdialysis probe. This … magnitude of increase in dopamine uptake produced by nor-…

Quantitative aspects of brain microdialysis

JL Peters, H Yang, AC Michael - Analytica chimica acta, 2000 - Elsevier
… Hence, our results show that recovery of dopamine from brain tissue by microdialysis probes
is an inefficient process and that blockade of the dopamine uptake mechanism increases …

Microdialysis for pharmacokinetic analysis of drug transport to the brain

ECM de Lange, BAG de Boer, DD Breimer - Advanced drug delivery …, 1999 - Elsevier
… This inevitably causes brain tissue trauma and may therefore … if intracerebral microdialysis
provides meaningful data on … By using the brain perfusion technique and initial uptake of a …

Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier

ECM de Lange, M Danhof, AG de Boer… - Brain research reviews, 1997 - Elsevier
tissue trauma by intracerebral microdialysis a number of histological studies has been
performed 10, 26, 43, 44, 50, 82, 93. Early tissue reactions after 10 hr of continuous microdialysis

Brain microdialysis and its applications in experimental neurochemistry

E Anderzhanova, CT Wotjak - Cell and tissue research, 2013 - Springer
… in vivo brain microdialysis, voltammetric methods, etc). We highlight practical aspects of
microdialysis … to increase the repertoire of their experimental techniques with brain microdialysis. …

In vivo cellular uptake of glutamate is impaired in the rat hippocampus during and after transient cerebral ischemia: a microdialysis extraction study

T Bruhn, T Christensen… - Journal of Neuroscience …, 2001 - Wiley Online Library
microdialysis in CA1 of the rat hippocampus, we studied the effect of transient cerebral
ischemia on in vivo uptake … to investigate uptake of glutamate in the intact rat brain in relation to …

Cerebral uptake of drugs in humans

RN Upton - Clinical and experimental pharmacology and …, 2007 - Wiley Online Library
Microdialysis was first described in 1974 as a method to … in subcutaneous tissues, but
further development saw microdialysis … This wider adoption of cerebral microdialysis probes in …

Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution

M Brunner, O Langer - The AAPS journal, 2006 - Springer
… 18F-labeled ciprofloxacin in several tissues over several hours in healthy volunteers 56
and patients with foot infections, 63 and we have compared intracerebral uptake of 11C-labled …

A method to evaluate the diffusion rate of drugs from a microdialysis probe through brain tissue

BHC Westerink, JB De Vries - Journal of neuroscience methods, 2001 - Elsevier
brain tissue, is not available at the present time. Here we describe a dual-probe microdialysis
… Rat brain nuclei that are infused by a microdialysis probe in dual–probe experiments have …

Pharmacological mitigation of tissue damage during brain microdialysis

KM Nesbitt, A Jaquins-Gerstl, EM Skoda… - Analytical …, 2013 - ACS Publications
… DA uptake activity in the tissue nearby the microdialysis probes. This robust DA uptake activity
… The responses observed after uptake inhibition by nomifensine, therefore, more directly …