… defined the quantitative relationship between the brain concentrations of fentanyl and the …
analysis of fentanyl disposition has often focused on the blood concentrations of fentanyl, it is …

… on fentanyl disposition. Overriding all this is the problem of experimental design not
being ideal or even uniform between studies. The condusions tend to be based on poor data. …

… a Median estimated organ/tissue weights in the 10 patients of the fentanyl study. b
Median estimated regional blood flows. c Distribution clearance, as determined in rats. …

… target organ (venous blood for IN and FEBT) with rate K2. Our objective here is to use
parsimonious mathematical expressions to estimate and compare the absorption kinetics for these …

… to characterize the disposition of fentanyl and alfentanil in 14 … barriers to fentanyl and alfentanil
in many organs and tissues … to predict the initial disposition of fentanyl and alfentanil. For …

… relating to organ drug elimination function and ABCB1 genetics for their association with
serum fentanyl and norfentanyl concentrations and metabolic ratio (MR) (norfentanyl : fentanyl). …

… For testes, we identified a total of three compounds, alfentanil, fentanyl, and thiopental
that fulfilled our criteria to be accepted as candidates for model development. For the thyroid, …

… Serum fentanyl measurements were performed for 278 … were evaluated to describe fentanyl
disposition. Covariates were … represent initial fentanyl exposure in well-perfused end-organs, …

… are given in comparison to fentanyl. Both were first … -fentanyl showed a similar potency as
fentanyl (8). Another study indicated that aliphatic derivatives might be less potent than fentanyl …

… of fentanyl PK–PD based on clinical data that can reconcile both arterial and venous plasma
fentanyl concentrations while using a target organ … any model of fentanyl disposition in man …