… to be transported across the blood-brain interface by a P-gp … that acute inflammatory brain
injury in human subjects would … of morphine, M3G, and M6G in the brain without altering the …

… as the most likely factor to cause prolonged opioid effects after morphine administration
in … that accumulation of M6G accounts for the increased potency of peroral morphine with …

… probably due to its reduced permeability across the blood brain barrier (93). The presence
of morphine metabolites in urine and their accumulation in hair (94) raises several questions. …

… brain barrier protection, by using morphine pretreatment, to allow doxorubicin accumulation
in the brain … macromolecules for the treatment of brain tumors or other human brain disease. …

… in morphine tolerance, sensitization and during morphine withdrawal. Whereas morphine …
Recent gene expression profiling studies reveal additional clusters of morphine‐responsive …

… It has been suggested that the accumulation of M3G that occurs with continued morphine …
glucuronidation had been demonstrated in postmortem human brain tissue, the rates of …

… Bianchi et al. have also shown that these neurones can accumulate tritiated morphine after
… -6-glucuronide following physiologic concentration of morphine in human brain. J. Toxicol. …

… Therefore, it was necessary to determine the stereochemical configuration of reticuline
produced by and accumulated in the human cell lines DAN-G and SH-SY5Y. Making use of the …

… This study focused on the short-term analgesic effects after morphine administration, in which
morphine alone is mainly responsible for the analgesic effects. Accumulation of morphine-6…

… this effect was observed after 1 or 3 days of morphine treatment. In the striatum, the reduction
of … , morphine administration did not influence levels of MC4-R mRNA in several other brain …