… counting of adjacent brain sections verifled high brain to cerebellar accumulation ratios, a
… with the radioligands, to completely block brain accumulation of labeled drug. These data …

BACKGROUND: There is great variability in the need for morphine in the postoperative
period. We performed a pharmacokinetic–pharmacodynamic study considering the potential …

… blood-brain barrier transport of morphine was affected by the absence of Pgp, using
microdialysis in mdr1a (−/−) and (+/+) mice. The concentrations of morphine in brain extracellular …

… human nervous system. Two clinical studies with intracerebroventricular (ICV) administration
of morphine have indicated that the human brain … morphine-treated patients, accumulation …

… metabolic pattern of morphine glucuronides in human (10) . … -brain barrier acts predominantly
in one way and polar glucuronides are more easily eliminated than accumulated in brain …

… morphine treatment resulted in increased brain morphine, … compared with rats treated with
morphine or ketamine only. This … the accumulation of morphine and norketamine to the brain. …

… between morphine and zinc, manganese, chromium, cadmium, lead, fluoride, their impact
on neural pathways associated with addiction, and on antinociception and morphine tolerance …

… Accumulation of fluoride in the brain has been shown to cause neurodegenerative
changes in the striatum, motor cortex, cerebellum, and amygdala of rats [9,10]. Studies on the …

… Although morphine caused maximal inhibition of cAMP accumulation in this study (Fig. 4A),
this may not be an optimal assay for the detection of partial agonists because only partial …

… accumulated findings demonstrate that several brain loci are closely related to the cause of
morphine … the neuronal plasticity involved in morphine analgesic tolerance and dependence …