The effect of old age on the disposition and antinociceptive response of morphine and morphine-6β-glucuronide in the rat
JT Van Crugten, AA Somogyi, RL Nation, G Reynolds - Pain, 1997 - Elsevier
… antinociception and pharmacokinetics with age, and suggest that blood-brain barrier
permeability and receptor sensitivity to morphine are not altered in aged rats. Accumulation of M3G …
permeability and receptor sensitivity to morphine are not altered in aged rats. Accumulation of M3G …
A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine
J Feng, S Lepetre-Mouelhi, A Gautier, S Mura… - Science …, 2019 - science.org
… observed not only in the inflamed paw but also in the liver, the spleen, and the lungs, whereas
no detectable accumulation of fluorescence occurred in the brain of the animals (fig. S9). …
no detectable accumulation of fluorescence occurred in the brain of the animals (fig. S9). …
Oxidative stress induced by morphine in brain of rats fed with a protein deficient diet
D Calderon-Guzman… - Human & …, 2009 - journals.sagepub.com
… In some neurodegenerative diseases in which tryptophan accumulate, it is … of morphine
sulfate on degree of oxidative stress in brain of malnourished rats, indicated by the levels in brain …
sulfate on degree of oxidative stress in brain of malnourished rats, indicated by the levels in brain …
Post-mortem levels and tissue distribution of codeine, codeine-6-glucuronide, norcodeine, morphine and morphine glucuronides in a series of codeine-related deaths
J Frost, TN Løkken, A Helland, IS Nordrum… - Forensic science …, 2016 - Elsevier
… A study of rats subjected to heroin and morphine overdose, on the other hand, found no
support for brain accumulation of morphine as an explanation for delayed deaths or formation of …
support for brain accumulation of morphine as an explanation for delayed deaths or formation of …
Acute effects of morphine on dopamine synthesis and release and tyrosine metabolism in the rat striatum
C Gauchy, Y Agid, J Glowinski, A Cheramy - European Journal of …, 1973 - Elsevier
… morphine injection, the initial accumulation of 3H-DA in tissues seen after the iv injection of
L-3,5-H-tyrosine was enhanced as well as the accumulation of … that morphine stimulated DA …
L-3,5-H-tyrosine was enhanced as well as the accumulation of … that morphine stimulated DA …
Proteomic analysis of rat cerebral cortex, hippocampus and striatum after exposure to morphine
A Bierczynska-Krzysik… - International …, 2006 - spandidos-publications.com
… In 1969 Oswald (1) began addressing human brain proteins, drugs and dreams, while Mackler
… At least 200 consecutive laser shots were accumulated in order to produce one spectrum. …
… At least 200 consecutive laser shots were accumulated in order to produce one spectrum. …
Morphine effects on human REM state, waking state and NREM sleep
DC Kay, RB Eisenstein, DR Jasinski - Psychopharmacologia, 1969 - Springer
… After an initial decrease in REMS by 30 mg/70 kg of morphine, an … morphine seen in
post-addicts needs further study in other populations and during the course of chronic morphine …
post-addicts needs further study in other populations and during the course of chronic morphine …
[HTML][HTML] Distribution of morphine and methadone to the brain in a developmental chicken embryo model
D Rajalingam, F Boix, A Khoder, JM Andersen… - Toxicology and Applied …, 2023 - Elsevier
… that the distribution of morphine to the brain followed a first-… , but not morphine, reduced μ
receptor (the main morphine … first to report the brain distribution of morphine, which can be …
receptor (the main morphine … first to report the brain distribution of morphine, which can be …
TNF alpha production in morphine-treated human neural cells is NF-κB-dependent
BE Sawaya, SL Deshmane, R Mukerjee, S Fan… - Journal of Neuroimmune …, 2009 - Springer
… of morphine receptors in these cells. We next demonstrated the ability of morphine to …
Accumulation of p65 in the nucleus following morphine treatment. a U937 cells were treated …
Accumulation of p65 in the nucleus following morphine treatment. a U937 cells were treated …
Development and validation of a reliable method for studying the distribution pattern for opiates metabolites in brain
K Guerrini, A Argo, C Borroni, D Catalano… - … of pharmaceutical and …, 2013 - Elsevier
… of morphine … of accumulation of heroin metabolites in a particular brain area and that the
analytes concentration in the nuclei was representative of morphine and codeine levels in brain …
analytes concentration in the nuclei was representative of morphine and codeine levels in brain …