… and codeine, and we found that the codeine-to-morphine ratio was higher in the brain than
in … In conclusion, we have found that codeine can accumulate in the brain tissue of suspected …

… on the analgesic effects of morphine6-glucuronide and morphine and reassess its effects on
… -6glucuronide does not accumulate in the body. We regard the effect on pain tolerance as …

… Accumulation of morphine in cultured primary bovine brain … In addition, morphine
accumulation in Chinese Purpose. … undertaken to assess morphine antinociception in mice lack- …

… We suppose that the effects of naloxone in humans may be … by an exogenous opiate like
morphine. This hypothesis rests … building on the knowledge accumulated during prior decades…

… In both cell lines, μ-opioid receptor tolerance can be assessed by the decreased effect of
morphine in inhibiting cAMP accumulation. The cAMP-dependent kinase can be activated by …

… Over the years, several mechanisms of OIH have been proposed, including the
accumulation of the pronociceptive morphine metabolite M3G (8–12), activation of the N-methyl-d-…

… SAH is reversibly converted to HCY and, since SAH accumulation can inhibit … Transsulfuration
of HCY to cysteine is restricted in the human brain, increasing reliance upon EAAT3-…

… nonneuronal pool(s) in the mouse brain (Nishibori et al. 1985). … state of brain histamine in
mice dependent on morphine or … -methylhistamine accumulation in mice undergoing morphine …

… of detecting the levels of morphine accumulated in the human hair over a period of time. …
period of morphine in human hair via gas chromatography–mass spectrometry (GC–MS). …

… of the human brain, including exogenous morphine actions [44–… may be related to its morphine
enhancing effect and its … beta I-40 accumulation after chronic brain hypoperfusion in rats. …