Unexpected variation of the codeine/morphine ratio following fatal heroin overdose
V Gambaro, A Argo, M Cippitelli… - Journal of Analytical …, 2014 - academic.oup.com
… and codeine, and we found that the codeine-to-morphine ratio was higher in the brain than
in … In conclusion, we have found that codeine can accumulate in the brain tissue of suspected …
in … In conclusion, we have found that codeine can accumulate in the brain tissue of suspected …
Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers
C Skarke, J Darimont, H Schmidt… - Clinical …, 2003 - Wiley Online Library
… on the analgesic effects of morphine6-glucuronide and morphine and reassess its effects on
… -6glucuronide does not accumulate in the body. We regard the effect on pain tolerance as …
… -6glucuronide does not accumulate in the body. We regard the effect on pain tolerance as …
Morphine antinociception is enhanced in mdr1a gene-deficient mice
J Zong, GM Pollack - Pharmaceutical research, 2000 - Springer
… Accumulation of morphine in cultured primary bovine brain … In addition, morphine
accumulation in Chinese Purpose. … undertaken to assess morphine antinociception in mice lack- …
accumulation in Chinese Purpose. … undertaken to assess morphine antinociception in mice lack- …
Opioid Peptides Endorphins in Pituitary and Brain: Studies on opiate receptors have led to identification of endogenous peptides with morphine-like actions.
A Goldstein - Science, 1976 - science.org
… We suppose that the effects of naloxone in humans may be … by an exogenous opiate like
morphine. This hypothesis rests … building on the knowledge accumulated during prior decades…
morphine. This hypothesis rests … building on the knowledge accumulated during prior decades…
Tolerance to morphine at the μ-opioid receptor differentially induced by cAMP-dependent protein kinase activation and morphine
Z Wang, W Sadée - European journal of pharmacology, 2000 - Elsevier
… In both cell lines, μ-opioid receptor tolerance can be assessed by the decreased effect of
morphine in inhibiting cAMP accumulation. The cAMP-dependent kinase can be activated by …
morphine in inhibiting cAMP accumulation. The cAMP-dependent kinase can be activated by …
Morphine induces hyperalgesia without involvement of µ-Opioid receptor or morphine-3-glucuronide
M Swartjes, RAG Mooren, AR Waxman, C Arout… - Molecular …, 2012 - Springer
… Over the years, several mechanisms of OIH have been proposed, including the
accumulation of the pronociceptive morphine metabolite M3G (8–12), activation of the N-methyl-d-…
accumulation of the pronociceptive morphine metabolite M3G (8–12), activation of the N-methyl-d-…
Morphine induces redox-based changes in global dna methylation and retrotransposon transcription by inhibition of excitatory amino acid transporter type 3–mediated …
… SAH is reversibly converted to HCY and, since SAH accumulation can inhibit … Transsulfuration
of HCY to cysteine is restricted in the human brain, increasing reliance upon EAAT3-…
of HCY to cysteine is restricted in the human brain, increasing reliance upon EAAT3-…
Histamine turnover in the brain of morphine-dependent mice
R Oishi, M Nishibori, Y Itoh, K Saeki, T Fukuda… - Naunyn-Schmiedeberg's …, 1988 - Springer
… nonneuronal pool(s) in the mouse brain (Nishibori et al. 1985). … state of brain histamine in
mice dependent on morphine or … -methylhistamine accumulation in mice undergoing morphine …
mice dependent on morphine or … -methylhistamine accumulation in mice undergoing morphine …
[HTML][HTML] Detection and accumulation of morphine in hair using GC–MS
H Khajuria, BP Nayak - Egyptian Journal of Forensic Sciences, 2016 - Elsevier
… of detecting the levels of morphine accumulated in the human hair over a period of time. …
period of morphine in human hair via gas chromatography–mass spectrometry (GC–MS). …
period of morphine in human hair via gas chromatography–mass spectrometry (GC–MS). …
[PDF][PDF] Converging cellular processes for substances of abuse: endogenous morphine
… of the human brain, including exogenous morphine actions [44–… may be related to its morphine
enhancing effect and its … beta I-40 accumulation after chronic brain hypoperfusion in rats. …
enhancing effect and its … beta I-40 accumulation after chronic brain hypoperfusion in rats. …