… between morphine dosing rates and time of day by examining diurnal variations in
analgesic dosing requirements in both “normal" and morbidly obese postoperative patients. …

… heart rate, and arterial blood pressure following the administration of morphine to a variety
of patients with acute myocardial infarctionand at the same time to observe the clinical effects. …

… compared to morphine levels in arterial blood. This report shows an increase in morphine
levels … The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, …

… The average morphine plasma clearance of 119 l h −1 in the patients in this study is in …
morphine in the subcutaneous adipose tissue was similar to the half-life for the total morphine …

… than morphine, patients with renal failure are at increased risk … morphine, cross the blood–brain
barrier with some delay when compared to the parent drug. We calculated a similar blood…

To assess the effects of iv injection of morphine, 0.5 mg/kg, hemodynamic studies were
performed on 24 critically ill patients under controlled ventilation. An esophageal balloon was …

… to follow 60 mg of intravenous morphine in a patient from the present study with … patient
to hypotension after intravenous morphine have not been identified by the present study; blood…

… The results of serial blood gas studies in most of our patients indicate that their respiratory
status, as measured by increasing PaCO2 and decreasing pH, steadily worsened during the …

… [46] When we consider the blood-effect site equilibration half-life (t ½ke0 ), human studies
indicate that M6G equilibrates slowly with the postulated effect-site within the CNS. Romberg …

… flow (19 per cent) after the administration of morphine. This … blood volume inanimals can
be extrapolated to human beings, an increase in splanchnic blood volume after morphine may …