… Buprenorphine is used clinically as an analgesic and as … focuses on the pharmacokinetics
of buprenorphine as they … sublingual doses of buprenorphine alone, buprenorphine with …

… Pharmacokinetic data revealed that plasma concentrations of … the clinical pharmacology
and safety profile of buprenorphine by testing a wide range of buprenorphine doses in humans …

… I pharmacokinetics (PK) studies in healthy volunteers. The first study compared the single-dose
PK of buprenorphine … F24) across a 16-fold range of doses. The formulations differed in …

… parameters of a single intravenous dose of buprenorphine given under carefully controlled
… pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic …

… At higher doses, it has demonstrated potential for treating … to investigate buprenorphine
pharmacokinetics by different routes … sublingual buprenorphine pharmacokinetics at doses of 0.4 …

… pharmacokinetics of a range of IV buprenorphine doses clinically relevant to the diversion of
SL buprenorphine … plasma buprenorphine concentrations increased in a linear dose-related …

… to buprenorphine from higher methadone doses, this study first determined the specific
sublingual buprenorphine dose … 24 h after their last 100 mg dose of methadone. Then, that same …

… and pharmacokinetic parameters of buprenorphine in dogs following intravenous (IV)
administration of clinical doses of the opioid. An IV bolus of 0.02 mg/kg buprenorphine was …

… pharmacokinetic data from three studies that were performed during the development of
Subutex® and Suboxone®. … of the pharmacokinetics of sublingual buprenorphine at high doses …

… variability in the pharmacokinetics (PK) of buprenorphine, the effective dose or effective
plasma concentration is also quite variable. Doses must be titrated to a clinically effective level …