… For MRI metrics to be used as surrogate marker of neurodegeneration, longitudinal studies
… with clinical progression. To address this issue we performed a spinal cord MRI longitudinal …

… Cross-sectional studies have shown that spinal cord volume (SCV) loss is related to disease
… as a biomarker of disease progression in comparison to other MRI measurements in a large …

… should not disregard the evaluation of spinal cord damage that has suggested as a major …
MRI techniques to the spinal cord damage has convincingly demonstrated that cord area, …

… A spinal cord MRI study of benign and secondary progressive multiple sclerosis. In: Proceedings
of The Society of Magnetic Resonance Third Scientific Meeting and Exhibition 1995a; 1…

… area, is also associated with disability progression, independently of other clinical and MRI
factors including … Two main markers of spinal cord pathology are explored using conventional …

… cord damage using DT-MRI and histogram analysis in patients with PPMS with the main
aim to provide a more accurate in vivo picture of cord pathology in this peculiar MS phenotype. …

… ratio or diffusion tension imaging indices with cord atrophy markers seem to be the most
robust … Asymptomatic spinal cord lesions predict disease progression in radiologically isolated …

… Challenges in the adoption of spinal cord atrophy as a marker of disability progression may
potentially be overcome in several different ways. For example, improvements in automated …

… Imaging of the spinal cord (SC) with magnetic resonance imaging (MRI) plays a central role
… As technical advances are made, SC imaging has the potential to provide markers able to …

… This study provides Class III evidence that MRI cervical spinal cord atrophy distinguishes …
those with RRMS without progression and individuals with RIS who are asymptomatic. …