Presence of reticuline in rat brain: A pathway for morphine biosynthesis

W Zhu, Y Ma, P Cadet, D Yu, TV Bilfinger… - Molecular brain …, 2003 - Elsevier
… small and large intestine and bacteria cultured from these tissues did not contain either
morphine or … that morphine biosynthesis may occur in rat neural tissues, and that its biosynthesis

Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues

F Aricioglu-Kartal, S Regunathan - Life sciences, 2002 - Elsevier
… if exposure to morphine could alter the metabolism of agmatine in rat brain as such changes
… in morphine dependence/withdrawal status. We report that rats exposed to morphine have …

The effect of morphine on rat brain catecholamines: turnover in vivo and uptake in isolated synaptosomes

DH Clouet, JC Johnson, M Ratner, N Williams… - Frontiers in …, 1973 - Elsevier
biosynthesis in the same area. In tolerant animals, the biosynthesis of DA was increased
in all areas of rat brain… during morphine treatment, the levels were increased in some brain

Morphine: new aspects in the study of an ancient compound

S Benyhe - Life sciences, 1994 - Elsevier
biosynthetic pathways for morphine exist in animal and even human tissues such as liver,
blood and brain… of which are identical to morphine) to rat brain synaptic plasma membrane …

Effects of morphine, in vitro and in vivo, on tyrosine hydroxylase activity in rat brain

TJ Cicero, CE Wilcox, BR Smithloff, ER Meyer… - Biochemical …, 1973 - Elsevier
… activity of the enzyme were determined in several regions of rat brain. … To determine whether
morphine enhanced … biosynthesis in the rat brain, rats were injected with either 0 (saline), …

Effects of morphine treatment on pro-opiomelanocortin systems in rat brain

DM Bronstein, R Przewlocki, H Akil - Brain research, 1990 - Elsevier
… estimate the dynamics of endogenous opioid biosynthesis. In the present studies, we re-examined
the question of morphine's effects on brain opioid systems, focusing in particular on …

Synthesis of the skeleton of the morphine molecule by mammalian liver

CJ Weitz, KF Faull, A Goldstein - Nature, 1987 - nature.com
… by rat liver, but this conversion is not detectable in rat brain … hypothesis that morphine and
codeine in brain and adrenal … morphinan biosynthesis, we administered ["H]reticuline to rats

Catecholamine biosynthesis in brains of rats treated with morphine

DH Clouet, M Ratner - Science, 1970 - science.org
morphine suggests that in the brains of tolerant rats, the catecholamine biosynthetic pathway
operates more effectively than it does in the brains of naive rats. … whole brain of tolerant rats

Biosynthesis of morphine in the animal kingdom

HW Kosterlitz - Nature, 1987 - nature.com
… codeine and free morphine in extracts of rat brain. Because in the morphine biosynthesis
of … in extracts of bovine adrenal gland and rat brain. Even then they still could not decide …

De novo biosynthesis of morphine in animal cells: An evidence-based model

RM Kream, GB Stefano - Medical Science Monitor, 2006 - medscimonit.com
… licated and extended the original anatomical observations of Spector and coworkers by
demonstrating uptake and accumulation of 3H-labeled morphine within defined rat brain areas […