The disposition of morphine in rat brain and serum was determined over 48 hr after
subcutaneous doses. Free morphine was measured by a specific assay using 3H-labeling …

A method is described for the estimation of N-C14-methyl labeled morphine in biological
materials, which is sensitive to a level of 4 to 5 millimicrograms. Concentrations of free …

Evidence for the specificity of the radioimmunoassay for morphine in plasma was provided
by demonstrating similar results with a fluorometric assay method which did not measure …

TOLERANCE of a very high grade and specificity is known to develop to morphine and its
congeners. Although no precise information is available on the biochemical and anatomical …

The distribution of free and" bound" morphine in dogs and rats is selective for certain tissues
and fluids." Bound" morphine is found in gall bladder bile in concentrations many fold …

Materials and Methods Animals. The subjects were male Wistar rats (TNO, Zeist, the
Netherlands), weighing approximately 220 g. They were maintained in a temperature …

Male Fischer rats were implanted SC with a total of six 75-mg morphine (base) pellets over 8
days and tested on the 11th day. On day 11 a dose of 0.15 mg/kg of naloxone precipitated …

The subcutaneous administration of 30 mgm./kgm. of morphine in nontolerant monkeys
results in the prompt appearance of free and bound morphine in the plasma, the maximum …

In order to determine the possible contribution of altered distribution of morphine in the
morphine tolerance process, the distribution of morphine was studied in brain regions and …

Physical dependence was induced in rats by administration of a slow release morphine
emulsion (morphine SR), and assessed by scoring abstinence signs and temperature …