Repeated opiate administration alters gene expression in different brain regions of rodents,
an effect which may contribute to plastic changes associated with addictive behaviour. There …

Opiate addiction is a central nervous system disorder of unknown mechanism. Neuronal
basis of positive reinforcement, which is essential to the action of opioids, relies on activation …

Addiction to opiates such as morphine is a major public health concern. A more thorough
understanding of the molecular mechanisms of opiate addiction can lead to better treatment …

Chronic exposure to opioids induces adaptations in brain function that lead to the formation
of the behavioral and physiological symptoms of drug dependence and addiction. Animal …

Opioid dependence may be associated with adaptive changes in gene expression in the
brain. In the present study we used DNA microarrays (U34A; Affymetrix) to analyze the …

Background Immediate early gene (IEG) induction elicited by drugs of abuse may contribute
to development of plastic changes in the brain responsible for drug-induced behavioral …

Chronic morphine treatment alters gene expression in brain structures. There are increasing
evidences showing a correlation, in gene expression modulation, between blood cells and …

Addictive drugs including opioids activate signal transduction pathways that regulate gene
expression in the brain. However, changes in CNS gene expression following morphine …

Morphine dependence is associated with long-term adaptive changes in the brain that
involve gene expression. Different behavioral effects of morphine are mediated by different …

Intermittent exposure to addictive drugs causes long‐lasting changes in responsiveness to
these substances due to persistent molecular and cellular alterations within the meso …