The cellular response to toxic stimuli is elicited through the expression of heat shock
proteins, a transcriptional process that relies upon conserved DNA elements in the …

We characterized the activity of a human hsp70 gene promoter by in vitro transcription.
Analysis of 5′ deletion and substitution mutants in HeLa nuclear extracts showed that the …

A CCAAT box-binding protein subunit, CBF-C/NF-YC, was cloned as a protein involved in
the c-Myc complex formed on the G 1-specific enhancer in the human hsp70 gene. CBF …

Heat shock factor (HSF) is an evolutionarily conserved stress‐response regulator that
activates the transcription of heat shock protein genes, whose products maintain protein …

The heat shock response has been characterized by the induction of major heat shock
proteins that suppress protein aggregation by facilitating protein folding. Recently, we found …

Our cells and tissues are challenged constantly by exposure to extreme conditions that
cause acute and chronic stress. Consequently, survival has necessitated the evolution of …

Heat shock proteins (HSP) are rapidly induced after proteotoxic stresses such as heat shock
and accumulate at high concentrations in cells. HSP induction involves primarily a family of …

Heat shock proteins (HSPs) are required for the clearance of damaged and aggregated
proteins and have important roles in protein homeostasis. It has been shown that the heat …

Heat shock transcription factor-1 (HSF-1) is the primary stress responsive transcription factor
that regulates expression of heat shock proteins (Hsps) in response to elevated temperature …

The basal promoter of the human hsp70 gene is predominantly controlled by a CCAAT
element at position–70 relative to the transcriptional initiation site. We report the isolation of …