Background Anesthetics may affect the regional cerebral blood flow (rCBF) response
associated with increased brain activity in humans. rCBF was measured as auditory stimulus …

Background Despite widespread use, little is known about the comparative
pharmacokinetics of intrathecally administered opioids. The present study was designed to …

BACKGROUND: Through their action on the locus coeruleus, α 2-adrenoceptor agonists
induce rapidly reversible sedation while partially preserving cognitive brain functions. Our …

In their paper they summarise four main findings. First, they report that it took about 40 min
for the sevoflurane concentration in arterial blood and jugular bulb blood to become the …

The ability of continuous infusions of opioids to control hypertension at the end of
neurosurgical procedures without compromising prompt emergence was studied in patients …

The purpose of this study was to correlate changes in cerebral blood flow velocity (Vmean)
with cerebral blood flow (CBF) during isoflurane anesthesia in dogs. The relation between …

Background The authors report a positron emission tomography (PET) study on humans
with parallel exploration of the dose-dependent effects of an intravenous (propofol) and a …

It is now approaching a quarter of a century since “selective spinal analgesia” was
suggested as a goal for the spinal administration of opioids (1). In an ensuing study of …

Background Etomidate is a widely used general anesthetic that has become a useful tool to
investigate mechanisms of anesthetic action in vivo and in brain slices. However, the free …

SUMMARY 1 Drugs that target the central nervous system (CNS) are under‐represented in
the pharmacopoeia because of the difficulties of overcoming passive and active defences of …