Materials and Methods: Data was collected during 10 neurosurgeries with combined
propofol/remifentanil anesthesia, using RugLoopII® software every 5 s from Aspect …

Background The effect of volatile anesthetics on cerebral blood flow depends on the
balance between the indirect vasoconstrictive action secondary to flow-metabolism coupling …

When a new drug is introduced into neuroanesthesia practice, several considerations must
be addressed. A principal concern is drug effect on cerebral perfusion pressure (CPP) …

The effects of iv alfentanil on the intracranial pressure (ICP) and cerebral perfusion pressure
(CPP) were prospectively evaluated during endotracheal suctioning of head-injured adults …

Background: The ability of the brain to preserve adequate cerebral blood flow (CBF) during
alterations in systemic perfusion pressure is of fundamental importance. At increasing …

Objective. The purpose of this project was to develop a computer model of cerebrovascular
hemodynamics interacting with a pharmacokinetic drug model to examine the effects of …

Background We have compared the pharmacokinetics and brain distribution of lidocaine,
racemic bupivacaine (bupivacaine), and levobupivacaine in awake, spontaneously …

Abstract Background. Propofol (2, 6-diisopropylphenol) is a widely used general anaesthetic
that modulates γ-aminobutyric acid type A (GABAA) receptors, the major inhibitory …

Infusions of catecholamines are frequently administered to patients receiving propofol or
isoflurane anaesthesia. Interactions between these drugs may affect regional circulations …

The objectives of this investigation were to characterize the disposition of fentanyl and
alfentanil in 14 tissues in the rat, and to create physiological pharmacokinetic models for …