A major reason for quantitating the relationship of drug dose to plasma concentration is to
design optimal drug administration schemes (ie, those that can achieve desired target …

Background It has been suggested that opioids may move from the epidural space to the
spinal cord by way of the spinal radicular arteries. However, there are no data that address …

Background Previous imaging studies have demonstrated a number of cortical and
subcortical brain structures to be activated during noxious stimulation and infusion of …

Background The pharmacokinetics and pharmacodynamics of remifentanil were studied in
65 healthy volunteers using the electroencephalogram (EEG) to measure the opioid effect …

The present study assessed the impact of time (6 h) on cerebral blood flow (CBF) during
isoflurane anesthesia with and without vasopressor administration. All animals were …

Whether desflurane and sevoflurane have clinical advantages over isoflurane in
neuroanesthesia is much debated. A porcine model was used for comparison of desflurane …

Electroencephalogram (EEG) effect parameters may be useful in pharmacokinetic-
pharmacodynamic modelling studies of drug effects on the central nervous system (CNS) …

This experiment was designed to study the effect of progressively increasing blood propofol
concentrations on cerebral blood flow (CBF), cerebral metabolic rate for oxygen (CMRO 2) …

We describe a six-compartment kinetic and dynamic physiological model of induction of
anaesthesia with thiopental. The model included an accurate account of initial drug …

BACKGROUND: Opioids have been linked to limbic system activation and, in animals, to
neurotoxicity. Limbic system nonpharmacologic activation patterns have been linked to the …