MRI and PET studies in ALS have consistently shown patterns of functional and structural
changes considered to be the pathological signature of the disease. The constant advance …

In patients with ALS, conventional MR imaging is frequently noninformative, and its use has
been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which a precise
cause has not yet been identified. Standard CT or MRI evaluation does not demonstrate …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving upper and
lower motor neurons, extra-motor neurons, microglia and astrocytes. The neurodegenerative …

Several neuroimaging modalities have been used with varying success to aid the clinical
process of establishing the diagnosis of amyotrophic lateral sclerosis (ALS). By …

Introduction: Several neuroimaging techniques have been used to define in vivo markers of
pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

Importance of the field: With the emergence of therapeutic candidates for the incurable and
rapidly progressive neurodegenerative condition of amyotrophic lateral sclerosis (ALS), it …

Amyotrophic lateral sclerosis (ALS) is now recognised to be a heterogeneous
neurodegenerative syndrome of the motor system and its frontotemporal cortical …

In the past two decades, structural and functional neuroimaging findings have greatly
modified longstanding notions regarding the pathophysiology of amyotrophic lateral …