Objective The involvement of upper motor neuron (UMN) degeneration is crucial to the
diagnosis of amyotrophic lateral sclerosis (ALS). However, it is difficult to detect in the early …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder
which is incurable to date. As there are many ongoing studies with therapeutic candidates, it …

Neurodegenerative process in amyotrophic lateral sclerosis (ALS) has been proven to
involve several cortical and subcortical brain regions within and beyond motor areas …

Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor
neuron disorder associated with considerable clinical disability. Symptoms are typically …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …

Introduction Primary lateral sclerosis is a rare neurodegenerative disorder of the upper
motor neurons. Diagnostic criteria have changed considerably over the years, and the …

Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Purpose Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain
degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with limited
treatment options. Despite decades of therapeutic development, only two modestly …