BACKGROUND AND PURPOSE: The extensive application of advanced MR imaging
techniques to the study of ALS has undoubtedly improved our knowledge of disease …

Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

Sensitive and specific surrogate measures of disease progression are most likely to be
based on direct measures of selective neuronal damage. The 'classical'view of selective …

Positron emission tomography (PET) has enabled us to study the human brain with
unrivalled sensitivity, and has already established its place in the research of neurological …

Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper
motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and …

Primary lateral sclerosis (PLS) is an adult-onset upper motor neuron disease manifesting in
progressive spasticity and gradually resulting in considerably motor disability. In the …

Objective To assess the performance of a combination of three quantitative MRI markers
(iron deposition, basal neuronal metabolism, and regional atrophy) for differential diagnosis …

Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …

Objective To characterize [11C]‐PBR28 brain uptake using positron emission tomography
(PET) in people with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) …

Background Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease
characterized by both upper and lower motor neuron degeneration. While neuroimaging …