Background and purpose Synaptic loss is well established as the major correlate of
characteristic and consistent pathology in amyotrophic lateral sclerosis (ALS). We aimed to …

BACKGROUND AND PURPOSE: Various lines of evidence implicate cerebral involvement
beyond the motor cortex in ALS, including the cingulate gyrus and the thalamus. The …

Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, is a motor neuron
disease characterized by progressive degeneration of upper motor neuron (UMN) and lower …

Background The criteria for assessing upper motor neuron pathology in pure lower motor
neuron disease (LMND) still remain a major issue of debate with respect to the clinical …

Objective To evaluate multimodal MRI of the spinal cord in predicting disease progression
and one-year clinical status in amyotrophic lateral sclerosis (ALS) patients. Materials and …

Object To evaluate the potential of quantitative MR techniques [voxel-based morphometry
(VBM), T2-relaxometry, mean diffusivity (MD), fractional anisotropy (FA)] in the diagnostics of …

It is agreed that conventional magnetic resonance imaging (MRI) of the brain and spine is
one of the core elements in the differential diagnostic work up of patients with clinical signs …

Background Up to 50% of amyotrophic lateral sclerosis (ALS) patients develop some degree
of cognitive dysfunction and a small proportion of these develop frontotemporal dementia …

The opening sentence of many papers concerning amyotrophic lateral sclerosis (ALS) will
inform the reader that it is a progressive, rapidly fatal neurodegenerative disorder …

Using diffusion tensor (DT) magnetic resonance imaging (MRI), damage to brain
intrahemispheric and interhemispheric connections was assessed in 26 sporadic primary …