Motor neuron damage and cortical spinal tract (CST) degeneration are pathological features
of amyotrophic lateral sclerosis (ALS). We combined whole-brain diffusion tensor imaging …

Introduction Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative
disorder primarily affecting upper and lower motor neurons. Due to relative fast progression …

Objective markers of disease sensitive to the clinical activity, symptomatic progression, and
underlying substrates of neurodegeneration are highly coveted in amyotrophic lateral …

BACKGROUND AND PURPOSE: The previous studies described phenotype-associated
imaging findings in amyotrophic lateral sclerosis (ALS) with a prior categorization of patients …

Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated
with cognitive and behavioral impairments and motor symptoms. Magnetic resonance …

There is an ongoing discussion whether ALS is primarily a disease of upper motor neurons
or lower motor neurons. We undertook a review to assess how new insights have …

Objective To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral
Sclerosis (ALS) progression. Methods Twenty-seven patients and 27 controls performed two …

Amyotrophic lateral sclerosis (ALS) is an incurable and progressively fatal
neurodegenerative disease that manifests with distinct clinical phenotypes, which are seen …

Background and aims Considering the great heterogeneity of amyotrophic lateral sclerosis
(ALS), the identification of accurate prognostic predictors is fundamental for both the clinical …

Background Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive
neurodegenerative disease that mainly affects the motor system. A number of potentially …