Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by
progressive muscle wasting, breathing and swallowing difficulties resulting in patient's death …

BACKGROUND AND PURPOSE: Frontotemporal lobar degeneration is responsible for the
cognitive abnormalities seen in patients with ALS. We sought to evaluate the in vivo …

Upper motor neuron (UMN) dysfunction in Amyotrophic Lateral Sclerosis (ALS) is not easy to
identify clinically: Diffusion Tensor Imaging (DTI) and single-voxel Magnetic Resonance …

Several quantitative magnetic resonance imaging (MRI) techniques have been proposed to
investigate microstructural tissue changes in amyotrophic lateral sclerosis (ALS) including …

Amyotrophic lateral sclerosis (ALS) is characterised by degeneration of upper (UMN) and
lower motor neurons (LMN). We aimed to relate clinical variables to cortical thinning of the …

Abstract Primary Lateral Sclerosis (PLS) is an uncommon motor neuron disorder. Despite
the well-recognisable constellation of clinical manifestations, the initial diagnosis can be …

Background Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically
heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid …

Objective: To determine identifiable subgroups of patients with primary lateral sclerosis
(PLS) with distinct clinical features as a first step in identifying patients likely to have the …

Purpose To assess brachial plexus magnetic resonance (MR) imaging features and limb-
girdle muscle abnormalities as signs of muscle denervation in patients with amyotrophic …

Purpose To establish the relationship between ALS histopathology and quantitative MRI
metrics. Materials and Methods ALS patients (N= 8) in advanced stages of the disease were …