A large multiparametric MRI study has been undertaken to evaluate anatomical patterns of
basal ganglia, white matter and cortical grey matter involvement in ALS. Unaffected brain …

Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …

In ALS, advanced magnetic resonance imaging (MRI) techniques are increasingly used to
investigate the underlying pathology. In this study, the technique of voxel‐based …

Amyotrophic lateral sclerosis (ALS) is associated with considerable clinical heterogeneity
spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent …

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with clinical,
pathological and genetic overlap with frontotemporal dementia (FTD). No longer viewed as …

We investigated 17 patients with sporadic amyotrophic lateral sclerosis (ALS) using voxel-
based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) at …

Abstract Amyotrophic Lateral Sclerosis (ALS) is recognized as a very complex disease. As
we have learned in the past 20 years from studies in patients and in models based on the …

Amyotrophic lateral sclerosis (ALS) is characterized phenotypically by progressive
weakness and neuropathologically by loss of motor neurons. Phenotypically, there is …

Background Body region of onset and functional disability are key components of disease
heterogeneity in amyotrophic lateral sclerosis (ALS). Objectives To evaluate patterns of grey …

Objective The purpose of this study was to identify subtypes of amyotrophic lateral sclerosis
(ALS) by comparing patterns of neurodegeneration using brain magnetic resonance …