New requirements must be considered when designing trials of new lung surfactants for
patients with acute lung injury (ALI). Radiographic inclusion criteria must be carefully …

The changes in the surfactant system of patients with acute lung injury and acute respiratory
distress syndrome form the rationale for the instillation of exogenous surfactant. There is …

Surfactant therapy for acute lung injury/acute respiratory d... : Current Opinion in Critical
Care Surfactant therapy for acute lung injury/acute respiratory distress syndrome : Current …

Objectives To outline both the preclinical and clinical data demonstrating surfactant
alterations in acute lung injury, which provide the rationale for testing exogenous surfactant …

Rationale: Compositional changes in surfactant and/or decreased surfactant content of the
lungs are common features in patients with acute respiratory failure. Instillation of …

This article reviews exogenous surfactant therapy and its use in mitigating acute lung injury
(ALI) and the acute respiratory distress syndrome (ARDS) in infants, children, and adults …

Rationale: Patients with acute lung injury have impaired function of the lung surfactant
system. Prior clinical trials have shown that treatment with exogenous recombinant …

Acute lung injury and acute respiratory distress syndrome (ARDS) are characterised by
severe hypoxemic respiratory failure and poor lung compliance. Despite advances in clinical …

The efficacy of surfactant replacement therapy for pediatric and adult lung injuries has been
an ongoing area of investigation for more than 25 years. Surfactant therapy is lifesaving in …

This chapter examines exogenous surfactant therapy and its utility in miti-gating clinical
acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Extensive …