Background After the demonstration of a corticoefferent propagation pattern in amyotrophic
lateral sclerosis (ALS) by neuropathological studies, this concept has been used for in vivo …

Background There is an ongoing debate whether primary lateral sclerosis (PLS) should be
regarded as an independent disease entity separate from amyotrophic lateral sclerosis …

A sequential transaxonal disease spread of amyotrophic lateral sclerosis (ALS)-associated
TDP-43 pathology in four stages has been defined by post-mortem data, which have been …

Objective Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a
dissemination in a regional sequence in four anatomically defined patterns. The aim of this …

This work evaluates the potential in diagnostic application of a new advanced neuroimaging
method, which delineates the profile of tissue properties along the corticospinal tract (CST) …

Background There is an ongoing debate about the concept of restricted phenotypes of
amyotrophic lateral sclerosis (ALS), including progressive bulbar palsy (PBP). Objective The …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative system disorder
affecting both upper and lower motor neurons. Despite supportive electrophysiological …

Purpose Diagnosis of amyotrophic lateral sclerosis (ALS) can be difficult from clinical
symptoms alone. Diffusion tensor imaging (DTI) has been suggested as an adjunct …

Our objective was to explore the value of additional MR contrasts in elucidating the
decrease in fractional anisotropy (FA) as has been observed in the corticospinal tracts (CST) …

Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for
cerebral microstructural alterations in neurodegenerative diseases is under investigation. In …