Background Primary lateral sclerosis is a progressive upper-motor-neuron disorder
associated with markedly longer survival than ALS. In contrast to ALS, the genetic …

Introduction Primary lateral sclerosis is a rare neurodegenerative disorder of the upper
motor neurons. Diagnostic criteria have changed considerably over the years, and the …

Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …

Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

Primary lateral sclerosis (PLS) bears close resemblance to cases of amyotrophic lateral
sclerosis (ALS) presenting with spasticity, but histopathological studies have shown …

Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system.
Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is …

Objectives Primary lateral sclerosis (PLS) is commonly considered as a motor neuron
disease (MND) variant which almost exclusively affects upper motor neurons (UMN). There …

Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

Abstract Primary Lateral Sclerosis (PLS) is an uncommon motor neuron disorder. Despite
the well-recognisable constellation of clinical manifestations, the initial diagnosis can be …

Aim To investigate whether primary lateral sclerosis (PLS) represents part of the
amyotrophic lateral sclerosis–frontotemporal dementia (ALS–FTD) spectrum of diseases …