Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor
neuron disorder associated with considerable clinical disability. Symptoms are typically …

Objective: To determine identifiable subgroups of patients with primary lateral sclerosis
(PLS) with distinct clinical features as a first step in identifying patients likely to have the …

Primary lateral sclerosis (PLS) is a rare neurodegenerative disorder at the upper motor
neurone extreme of the spectrum of motor neurone disease. The diagnosis is clinical and …

Background and objectives Primary lateral sclerosis (PLS) is a motor neuron disease
characterised by loss of the upper motor neurons. Most patients present with slowly …

Increased interest in the underlying pathogenesis of primary lateral sclerosis (PLS) and its
relationship to amyotrophic lateral sclerosis (ALS) has corresponded to a growing number of …

Objective: Primary lateral sclerosis (PLS) is a rare form of motor neuron disease
characterised by UMN degeneration leading to slowly progressive spasticity. Whether it is a …

Primary lateral sclerosis (PLS) is a disorder of progressive upper motor neuron dysfunction,
in the absence of clinical signs of lower motor neuron involvement or family history …

OBJECTIVE To describe the clinical, neurophysiological, and MRI findings in 10 patients
with primary lateral sclerosis (PLS). RESULTS The course of the disease was very slowly …

In September 2019, a group of international neurologists gathered in Gold Coast, Australia,
to deconstruct the diagnostic process for amyotrophic lateral sclerosis (ALS) and to try to …

Primary lateral sclerosis (PLS) has been defined as a rare. Non-hereditary disease
characterized by progressive spinobulbar spasticity, related to the exclusive involvement of …