Purpose To investigate the patterns of cortical thinning and white matter tract damage in
patients with lower motor neuron (LMN)–predominant disease compared with healthy …

Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of upper
and lower motor neurons, with variable involvement of extramotor brain regions. Currently …

Introduction: Several neuroimaging techniques have been used to define in vivo markers of
pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence …

Neurodegenerative process in amyotrophic lateral sclerosis (ALS) has been proven to
involve several cortical and subcortical brain regions within and beyond motor areas …

Objective To characterize [11C]‐PBR28 brain uptake using positron emission tomography
(PET) in people with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) …

Background Despite significant advances in quantitative neuroimaging, the diagnosis of
ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis …

Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper
motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and …

Objective The purpose of this study was to identify subtypes of amyotrophic lateral sclerosis
(ALS) by comparing patterns of neurodegeneration using brain magnetic resonance …

Background Body region of onset and functional disability are key components of disease
heterogeneity in amyotrophic lateral sclerosis (ALS). Objectives To evaluate patterns of grey …

Importance Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily
affecting the motor system, with extramotor involvement to a variable extent. Biomarkers for …