Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) lie at
opposing ends of a clinical, genetic, and neuropathological continuum. In the last decade, it …

Degeneration of the primary motor cortex is a defining feature of amyotrophic lateral
sclerosis (ALS), which is associated with the accumulation of microscopic protein …

Background Diagnostic uncertainty in ALS has serious management implications and
delays recruitment into clinical trials. Emerging evidence of presymptomatic disease-burden …

There is significant clinical and prognostic heterogeneity in the neurodegenerative disorder
amyotrophic lateral sclerosis (ALS), despite a common immunohistological signature …

Background and aims Considering the great heterogeneity of amyotrophic lateral sclerosis
(ALS), the identification of accurate prognostic predictors is fundamental for both the clinical …

Motor neuron disease is an umbrella term encompassing a multitude of clinically
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …

Numerous neuroimaging studies in amyotrophic lateral sclerosis (ALS) have reported links
between structural changes and clinical data; however phenotypic and disease course …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by
functional connectivity alterations in both motor and extra-motor brain regions. Within the …

Objective To investigate the progression of resting-state functional connectivity (rs-FC)
changes in patients with amyotrophic lateral sclerosis (ALS) and their relationship with …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor
neurons in the cerebral cortex, brainstem, and spinal cord, brain regions in which …