We have investigated the pharmacological properties of B8805-033 [(±)-1, 3, 5-trimethyl-6-
[[3-[4-((2, 3-dihydro-2-hydroxymethyl)-1, 4-benzodioxin-5-yl)-1-piperazinyl] propyl] amino]-2 …

Objective To evaluate the histological structure of benign prostatic hyperplasia (BPH) and its
relationship with the density of α1‐adrenoceptors in smooth muscle. Materials and methods …

The present study was designed to compare the area density of smooth muscle, and the
binding and functional properties of alphai adrenoceptors in 8 different regions of the canine …

The subtype of α1-adrenoceptor mediating noradrenaline-induced contractile responses in
isolated mouse prostate glands was investigated. Adrenoceptor agonists were able to …

Purpose: Although α1L-adrenoceptor is recognized as a target of α1 antagonist therapy for
benign prostatic hyperplasia, the most common techniques, such as immunohistochemistry …

Molecular cloning studies have revealed the existence of three subtypes of alpha 1-
adrenergic receptors. However, the link between any individual subtype and its functional …

The aim of this study was to compare with known reference standards the functional in vitro
alpha-1 antagonistic activity of Rec 15/2739 on noradrenaline-induced contractions of …

1 The subtype of α1‐adrenoceptor mediating contractions of human prostate to
noradrenaline was characterized by use of a range of competitive and non‐competitive …

We have systematically reviewed the presence, functional responses and regulation of α1‐,
α2‐and β‐adrenoceptors in the bladder, urethra and prostate, with special emphasis on …

KMD-3213,(−)-(R)-1-(3-hydroxypropyl)-5-[2-[[2-[2-(2, 2, 2-trifluoroethoxy) phenoxy] ethyl]
amino] propyl] indoline-7-carboxamide, is a novel and selective α1A-adrenoceptor …