Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans

AS Flett, MP Hayward, MT Ashworth, MS Hansen… - Circulation, 2010 - Am Heart Assoc
Background—Diffuse myocardial fibrosis is a final end point in most cardiac diseases. It is
missed by the cardiovascular magnetic resonance (CMR) late gadolinium enhancement …

[HTML][HTML] Histological Validation of measurement of diffuse interstitial myocardial fibrosis by myocardial extravascular volume fraction from Modified Look-Locker …

CM de Ravenstein, C Bouzin, S Lazam, J Boulif… - Journal of …, 2015 - Elsevier
Abstract Background Gadolinium (Gd) Extracellular volume fraction (ECV) by
Cardiovascular Magnetic Resonance (CMR) has been proposed as a non-invasive method …

Diffuse myocardial fibrosis in severe aortic stenosis: an equilibrium contrast cardiovascular magnetic resonance study

AS Flett, DM Sado, G Quarta, M Mirabel… - European Heart …, 2012 - academic.oup.com
Aims Haemodynamics alone do not fully explain symptoms and prognosis in clinically
severe aortic stenosis (AS). Myocardial disease, specifically diffuse myocardial fibrosis …

[HTML][HTML] Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus …

EB Schelbert, SM Testa, CG Meier, WJ Ceyrolles… - Journal of …, 2011 - Elsevier
Background Myocardial extravascular extracellular volume fraction (Ve) measures quantify
diffuse fibrosis not readily detectable by conventional late gadolinium (Gd) enhancement …

Evaluation of Diffuse Myocardial Fibrosis in Heart Failure With Cardiac Magnetic Resonance Contrast-Enhanced T1 Mapping

L Iles, H Pfluger, A Phrommintikul, J Cherayath… - Journal of the American …, 2008 - jacc.org
Objectives: The purpose of this study was to investigate a noninvasive method for
quantifying diffuse myocardial fibrosis with cardiac magnetic resonance imaging (CMRI) …

Human non-contrast T1 values and correlation with histology in diffuse fibrosis

S Bull, SK White, SK Piechnik, AS Flett, VM Ferreira… - Heart, 2013 - heart.bmj.com
Background Aortic stenosis (AS) leads to diffuse fibrosis in the myocardium, which is linked
to adverse outcome. Myocardial T1 values change with tissue composition. Objective To test …

Histological validation of cardiac magnetic resonance analysis of regional and diffuse interstitial myocardial fibrosis

LM Iles, AH Ellims, H Llewellyn, JL Hare… - European Heart …, 2015 - academic.oup.com
Aim Myocardial fibrosis is fundamental in the pathogenesis of heart failure. Late gadolinium
enhancement (LGE) with cardiac magnetic resonance (CMR) imaging is commonly …

[HTML][HTML] Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials

S Liu, J Han, MS Nacif, J Jones, N Kawel… - Journal of …, 2012 - Elsevier
Background Cardiac magnetic resonance (CMR) T1 mapping has been used to characterize
myocardial diffuse fibrosis. The aim of this study is to determine the reproducibility and …

Gadolinium-enhanced magnetic resonance imaging for detection and quantification of fibrosis in human myocardium in vitro

E Kehr, M Sono, SS Chugh… - The international journal of …, 2008 - Springer
Background The availability of a non-invasive test to detect and quantify interstitial and
replacement fibrosis would be a useful advance for evaluation of cardiac therapies that …

Assessment of myocardial fibrosis with cardiovascular magnetic resonance

N Mewton, CY Liu, P Croisille, D Bluemke… - Journal of the American …, 2011 - jacc.org
Diffuse interstitial or replacement myocardial fibrosis is a common feature of a broad variety
of cardiomyopathies. Myocardial fibrosis leads to impaired cardiac diastolic and systolic …