Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide

A Astrup, R Carraro, N Finer, A Harper… - International journal of …, 2012 - nature.com
Objective: Having demonstrated short-term weight loss with liraglutide in this group of obese
adults, we now evaluate safety/tolerability (primary outcome) and long-term efficacy for …

Weight loss with liraglutide, a once‐daily human glucagon‐like peptide‐1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily …

J Jendle, MA Nauck, DR Matthews… - Diabetes, Obesity …, 2009 - Wiley Online Library
Aim: The effect on body composition of liraglutide, a once‐daily human glucagon‐like
peptide‐1 analogue, as monotherapy or added to metformin was examined in patients with …

Efficacy and safety of liraglutide versus placebo added to basal insulin analogues (with or without metformin) in patients with type 2 diabetes: a randomized, placebo …

A Ahmann, HW Rodbard, J Rosenstock… - Diabetes, Obesity …, 2015 - Wiley Online Library
Aim To confirm the superiority, compared with placebo, of adding liraglutide to pre‐existing
basal insulin analogue±metformin in adults with inadequately controlled type 2 diabetes …

Efficacy and safety comparison between liraglutide as add-on therapy to insulin and insulin dose-increase in Chinese subjects with poorly controlled type 2 diabetes …

C Li, J Li, Q Zhang, L Lv, R Chen, C Lv, P Yu… - Cardiovascular …, 2012 - Springer
Objective To assess the efficacy and safety of adding liraglutide to established insulin
therapy in poorly controlled Chinese subjects with type 2 diabetes and abdominal obesity …

One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with …

R Pratley, M Nauck, T Bailey… - … journal of clinical …, 2011 - Wiley Online Library
Aim: The aim of this study was to compare the efficacy and safety of once‐daily human
glucagon‐like peptide‐1 analogue liraglutide with dipeptidyl peptidase‐4 inhibitor …

Achieving a clinically relevant composite outcome of an HbA1c of< 7% without weight gain or hypoglycaemia in type 2 diabetes: a meta‐analysis of the liraglutide …

B Zinman, WE Schmidt, A Moses… - Diabetes, Obesity and …, 2012 - Wiley Online Library
Aim: Effective type 2 diabetes management requires a multifactorial approach extending
beyond glycaemic control. Clinical practice guidelines suggest targets for HbA1c, blood …

The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 …

H Harder, L Nielsen, TDT Thi, A Astrup - Diabetes care, 2004 - Am Diabetes Assoc
OBJECTIVE—Glucagon-like peptide (GLP)-1 is a gut hormone that exerts incretin effects
and suppresses food intake in humans, but its therapeutic use is limited due to its short half …

Effects of liraglutide (NN2211), a long‐acting GLP‐1 analogue, on glycaemic control and bodyweight in subjects with type 2 diabetes

MN Feinglos, MF Saad, FX Pi‐Sunyer, B An… - Diabetic …, 2005 - Wiley Online Library
Aims Liraglutide (NN2211) is a long‐acting GLP‐1 analogue, with a pharmacokinetic profile
suitable for once‐daily administration. This multicentre, double‐blind, parallel‐group, double …

Long‐term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2‐year results from the LEAD‐2 …

M Nauck, A Frid, K Hermansen… - Diabetes, Obesity …, 2013 - Wiley Online Library
Aims To investigate efficacy and safety of dual therapy with liraglutide and metformin in
comparison to glimepiride and metformin, and metformin monotherapy over 2 years in …

Liraglutide, a once‐daily human GLP‐1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control …

M Marre, J Shaw, M Brändle, WMW Bebakar… - Diabetic …, 2009 - Wiley Online Library
Aim To compare the effects of combining liraglutide (0.6, 1.2 or 1.8 mg/day) or rosiglitazone
4 mg/day (all n≥ 228) or placebo (n= 114) with glimepiride (2–4 mg/day) on glycaemic …