In order to analyze the effects of the opioid agonist fentanyl on cells of the innate immune
system, seven healthy individuals were treated intravenously with the opioid fentanyl and …

Exposure to drugs, either ethical pharmaceuticals or illicit street drugs, often results in
medical complications, including alterations in the immune system. Among the drugs …

Opioids, including fentanyl, are often administered to patients who may be at risk for the
consequences of impaired immune function. We performed a clinical study to test the effects …

It is known that morphine has a negative impact on the immune responses. The potent
opioids fentanyl and buprenorphine have recently become available as transdermal …

Interactions between opiates and the human immune system have important clinical
implications. To further evaluate these interactions, we studied in vitro and in vivo effects of …

Opiates and opioid agents are known to affect the immune system. In humans this includes
alterations in natural killer (NK) cell activity. Morphine is reported to reduce in vivo spleen …

The immunoregulatory effects of fentanyl and a fentanyl-related compound, OHM3295, were
studied in mice. Male CD1 mice treated with a range of fentanyl doses (0.1–1.0 mg/kg …

Previous work has shown that morphine suppresses the pulmonary immune response to
infection and reduces pulmonary inflammation. No published studies have addressed the …

The effects of acutely-administered morphine on mitogen stimulated lymphocyte proliferation
and natural killer cell cytolytic activity were investigated. Two hours after a subcutaneous …

Opiates modulate a variety of immune responses of peripheral blood mononuclear cells
(PBMC). When PBMC were treated with morphine for 24 h, cells released less (P< 0.05) …