Background: During pathologic conditions such as meningitis and traumatic brain injury the
function of the blood–brain barrier (BBB) is disturbed. In the present study we examined the …

Intracerebral microdialysis was utilised to obtain information regarding how morphine is
transported across the blood–brain barrier (BBB). In a patient with a severe brain injury, we …

Aims In experimental studies, morphine pharmacokinetics is different in the brain compared
with other tissues due to the properties of the blood–brain barrier, including action of efflux …

The unbound concentration of morphine in striatum of rats was estimated during a constant
rate infusion of morphine 14 μmol/h∗ kg, by use of the microdialysis technique and …

Objective: In animals, central nervous system inflammation increases drug accumulation in
the brain partly due to a loss of central nervous system drug efflux transporter function at the …

In order to determine the rate and degree of redistribution of morphine within the
cerebrospinal fluid (CSF), and whether it was affected by the site of and volume of the …

Purpose. To quantify the contribution of distributional processes across the blood-brain
barrier (BBB) to the delay in antinociceptive effect of morphine in rats. Methods. Unbound …

BACKGROUND: Despite widespread use of chronic intrathecal (IT) infusions of morphine,
there is little systematic human work evaluating the steady state morphine concentrations or …

Forty patients undergoing arthroscopy were given an epidural dose of 0.05 mg morphine‐
HCl in 0.1 ml saline/kg body weight to study the disposition of morphine in the cerebrospinal …

Two groups of surgical patients each comprising six individuals received an intrathecal
injection of morphine 0.3 mg or meperidine 10 mg. Cerebrospinal fluid (CSF) and plasma …