Alzheimer's disease variant portal: a Catalog of genetic findings for Alzheimer's disease

PP Kuksa, CL Liu, W Fu, L Qu, Y Zhao… - Journal of …, 2022 - content.iospress.com
Background: Recent Alzheimer's disease (AD) genetics findings from genome-wide
association studies (GWAS) span progressively larger and more diverse populations and …

NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge

E Greenfest‐Allen, O Valladares… - Alzheimer's & …, 2024 - Wiley Online Library
Abstract INTRODUCTION The National Institute on Aging Genetics of Alzheimer's Disease
Data Storage Site Alzheimer's Genomics Database (GenomicsDB) is a public knowledge …

Large‐scale sequencing studies expand the known genetic architecture of Alzheimer's disease

D Xue, WS Bush, AE Renton… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Genes implicated by genome‐wide association studies and family‐based
studies of Alzheimer's disease (AD) are largely discordant. We hypothesized that genes …

Interpretation of 10 years of Alzheimer's disease genetic findings in the perspective of statistical heterogeneity

S Gao, T Wang, Z Han, Y Hu, P Zhu… - Briefings in …, 2024 - academic.oup.com
Common genetic variants and susceptibility loci associated with Alzheimer's disease (AD)
have been discovered through large-scale genome-wide association studies (GWAS) …

Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data

Y Wang, C Sarnowski, H Lin, AN Pitsillides… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Genome‐wide association studies (GWAS) have identified loci associated
with Alzheimer's disease (AD) but did not identify specific causal genes or variants within …

The complex genetic architecture of Alzheimer's disease: novel insights and future directions

SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

Genomic variants, genes, and pathways of Alzheimer's disease: An overview

AC Naj, GD Schellenberg… - American Journal of …, 2017 - Wiley Online Library
Alzheimer's disease (AD)(MIM: 104300) is a highly heritable disease with great complexity
in its genetic contributors, and represents the most common form of dementia. With the …

An overview of genome-wide association studies in Alzheimer's disease

L Shen, J Jia - Neuroscience bulletin, 2016 - Springer
Genome-wide association studies (GWASs) have revealed a plethora of putative
susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene …

Genetic Loci Associated With Alzheimer's Disease

C Reitz - Future neurology, 2014 - Taylor & Francis
EVALUATION OF: Lambert JC, Ibrahim-Verbaas CA, Harold D et al. Meta-analysis of 74,046
individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat. Genet. 45 (12) …

Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis

M Wainberg, SJ Andrews, SJ Tripathy - Alzheimer's Research & Therapy, 2023 - Springer
Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …